
At first glance, distinguishing between normal fat and lipedema fat might not be apparent. However, under microscopic examination, several differences become evident, and practical experiences have shown that lipedema fat behaves differently.
Microscopic Characteristics of Lipedema Fat
Microscopic analysis of lipedema adipose tissue reveals a slightly increased number of inflammation cells, indicating a mild, chronic inflammation. These inflammation cells could explain typical lipedema symptoms, including spontaneous pain, a tendency to swell, and unexplained bruises.
Chronic Inflammation and Symptoms
The ongoing inflammation within lipedema fat is believed to be the cause of the associated symptoms. Current research focuses on understanding the exact mechanisms of this inflammation to better manage the condition .
Altered Metabolism in Lipedema Fat
Lipedema fat appears to have a disrupted metabolism, storing fats but struggling to release them. This could explain why traditional measures like diets and exercise often fail to reduce lipedema fat.
Sensitivity to Hormonal Changes
Lipedema fat is particularly sensitive to changes in a woman's hormonal balance. The onset of lipedema during puberty, the first significant hormonal change in a woman's life, suggests a strong link between lipedema and hormonal influences.
Resistance to Reduction through Diet and Exercise
Due to its altered metabolism, lipedema fat cannot be reduced through conventional means such as diet and exercise. This poses a significant challenge for individuals, who often find that their efforts to lose weight have little impact on lipedema fat.
Distinguishing Lipedema from Other Conditions

Several other disorders besides lipedema, including lymphedema, obesity, and lipohypertrophy, exhibit symptoms that are closely similar.
Obesity
Obesity is marked by a non-painful increase in fat tissue around the trunk, altering the entire body silhouette proportionally, unlike the disproportional change seen in lipedema. Pain is not typical in obesity.
Lipohypertrophy
Lipohypertrophy resembles lipedema but does not cause pain. It is defined by a localized increase in fat tissue.
Lymphedema
Lymphedema arises from damage to the lymphatic system, whether congenital or acquired through tumors, surgery, or accidents. Unlike lipedema, lymphedema often affects only one leg or arm and includes the feet and hands, areas spared in lipedema unless the lymphatic system is overwhelmed.
Consulting a Medical Professional
Consulting with a medical professional is always recommended to confirm and assure an accurate diagnosis and appropriate treatment. At Flowell, we believe in empowering our community with knowledge and support, offering best-in-class compression therapy devices that help you manage your condition and find relief.
Embracing Strength with Flowell
Understanding lipedema and its distinguishing features is essential for effective management. While traditional methods like diet and exercise may not reduce lipedema fat, comprehensive strategies including compression therapy, nutritional balance, and physical activity can help. Flowell is here to support you every step of the way, helping you reclaim your life on your terms. You are not alone in this journey—let’s turn these challenges into opportunities for growth and resilience.
